Every
living organism contains within itself the information it needs
to build a new organism. This information, you could think of
it as a blueprint of life, is stored in the organism's genome.
The genome is made up of a material called DNA, which stands
for deoxyribonucleic acid. If you take a
really, really close look at the DNA molecule you will see that
it looks like an ordinary ladder, although somewhat twisted.
The steps that connects the two strands in this ladder are composed
of four different molecules of the same type, called nucleotides.
In DNA they are A, T, C and G; where A stands for adenine, T
for thymine, C for cytosine and finally G for guanine.
RNA - a Blueprint Copy
When
an organism needs to use the data stored in the genome, e.g.
to build components of a new cell, a copy of the required DNA
part is made. This copy is called RNA and is almost identical
to DNA. Just like DNA, RNA is an abbreviated form of a chemical
name which in the case of RNA is ribonucleic acid. Unlike the
double stranded DNA, RNA is only made up of a single strand.
Furthermore, the base T, thymine, is replaced by U, uracil in
RNA. This RNA string is used by the organism as a template when
it builds protein molecules, sometimes called the building blocks
of the body. For example, your muscles and hair are mostly made
up of proteins.
Amino Acids Make Up the
Protein
Proteins can vary in
length and size and look very different, but they are all composed
of smaller units, i.e. molecules called amino acids. Inside our
body there are 20 amino acids all with different chemical and
physical properties. In the table below their names and abbreviations
can be found.
Name
Abbrev.
Short Abbrev.
alanine
Ala
A
arginine
Arg
R
asparagine
Asn
N
aspartic acid
Asp
D
cysteine
Cys
C
glutamine
Gln
Q
glutamic acid
Glu
E
glycine
Gly
G
histidine
His
H
isoleucine
Ile
I
leucine
Leu
L
lysine
Lys
K
methionine
Met
M
phenylalanine
Phe
F
proline
Pro
P
serine
Ser
S
threonine
Thr
T
tryptophan
Trp
W
tyrosine
Tyr
Y
valine
Val
V
But how does the organism
know how to assemble these proteins compromising of the different
amino acids? How can the organism "read" the RNA, the blueprint
copy, and how is the information written in the RNA?
The RNA Message
Can you decode the message in
the RNA string?
The alphabet
in the RNA molecule contains 4 letters, i.e. A, U, C, G as previously
mentioned. To construct a word in the RNA language, three of
these letters are grouped together. This three-letter word are
often referred to as a triplet or a codon. An example of such
a codon is ACG. The letters don't have to be of different kinds,
so UUU is also a valid codon. These codons are placed after each
other in the RNA molecule, to construct a message, a RNA sequence.
This message will later be read by the protein producing machinery
in the body.
The RNA part to the left contains 39 letters
and since each codon contains 3 letters, 13 codons are present
(39 letters divided by 3 letters equals 13 words or codons.)
But how does these RNA words get interpreted
by the organism into the final product, the protein?
Interpreting the Message
Every
organism has an almost identical system that is able to read
the RNA, interpret the different codons and construct a protein
with various combinations of the amino acids mentioned previously.
In fact every RNA word or codon, corresponds to one single amino
acid. These codons and their correlation with the amino acids
in a protein sequence is what defines the genetic code. Below
is a schematic animation of this process displayed.
Visualizing the Code
One way to
visualize the genetic code, the connection between a codon and
an amino acid, is with a table. In the example below, the letter
in the outermost left column represents the first letter in the
codon. The letters in the top row represents the second codon
letter and finally the letters in the outermost right column
represents the third codon letter.
U
C
A
G
U
Phe
Ser
Tyr
Cys
U
Phe
Ser
Tyr
Cys
C
Leu
Ser
STOP
STOP
A
Leu
Ser
STOP
Trp
G
C
Leu
Pro
His
Arg
U
Leu
Pro
His
Arg
C
Leu
Pro
Gln
Arg
A
Leu
Pro
Gln
Arg
G
A
Ile
Thr
Asn
Ser
U
Ile
Thr
Asn
Ser
C
Ile
Thr
Lys
Arg
A
Met
Thr
Lys
Arg
G
G
Val
Ala
Asp
Gly
U
Val
Ala
Asp
Gly
C
Val
Ala
Glu
Gly
A
Val
Ala
Glu
Gly
G
The genetic code is
an important key in the understanding of the process in the
body when the DNA copy - RNA, is translated into the functional
molecules, the proteins.