Interview with Michael S. Brown, 1985 Nobel Laureate in Physiology or Medicine, at University of Texas Southwestern Medical Center, Dallas, in April 2007. The interviewer is Adam Smith, Editor-in-Chief of Nobelprize.org.

Michael Brown talks about his scientific beginnings, the inspiration provided by one of his early mentors (4:34), the path that led him to the University of Texas Southwestern Medical Center in Dallas (8:45), the importance of applying basic science to medical research (17:25), his unique working relationship with Nobel Prize co-recipient Joseph Goldstein (21:00), the essential attributes needed for good clinical research (41:30), and the current challenges in drug discovery (46:40).