The Nobel Prize in Physiology or Medicine 1993
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A precursor-RNA may often be matured to mRNAs with
alternative structures. An example where
alternative splicing has a dramatic
consequence is somatic sex determination in the fruit
fly Drosophila melanogaster.
In this system, the female-specific sxl-protein is a key regulator. It controls a cascade of alternative RNA splicing decisions that finally result in female flies. |
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Sex in Drosophila is largely determined by alternative splicing |
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