The Nobel Prize in Physiology or Medicine 1999

In many inherited diseases, proteins are mislocalized in the cell due to errors in targeting signals and transport. One example is "primary hyperoxaluria," a rare disease, which results in kidney stones already at an early age. A signal in the enzyme alanine:glyoxylate aminotransferase normally directs it to the peroxisome. In patients, this signal is altered and the protein is mislocalized to the mitochondrion where it is unable to perform its normal function.

Contents:
Start » Introduction » Protein synthesis » Signal sequences » Industrial synthesis » Diseases »
These pages are based on material from the 1999 Physiology or Medicine Nobel Poster. Credits and references for the poster »