Interview with Johann Deisenhofer, 1988 Nobel Laureate in Chemistry, at University of Texas Southwestern Medical Center, Dallas, Texas, on 25 April 2007. The interviewer is Adam Smith, Editor-in-Chief of Nobelprize.org.

Johann Deisenhofer talks about his scientific beginnings, what made co-Laureate Robert Huber a unique mentor (5:08), why people failed to realise the importance of Hartmut Michel's groundbreaking experiment (11:28) and how this allowed the three researchers to discover their breakthrough almost without competition (39:13), and how the field of structural biology has changed and how it needs to evolve (43:52).