Perspective
The achievements by
Deisenhofer, Huber and Michel that were recognized
with the 1988 Nobel Prize in chemistry signify
breakthroughs in several fields of
research:
Photosynthesis:
The knowledge about the location of the
photochemically active groups in the reaction center
has resulted in a deeper understanding of the
mechanism of the primary reaction in photosynthetic
organisms.
The structural analogies with plants will facilitate
the development of new, selective herbicides which
affect the function of the reaction
center.
Electron
transport:
For the first time it is shown how the
electron-carrying groups are organized spatially in a
biological system. This gives a possibility to
investigate current theories of electron
transfer.
The structure of
membrane proteins:
One will now be able to make better predictions of
the structures of other membrane proteins from their
amino acid sequence.
Crystallization of
membrane proteins:
Michel's crystallization method can be applied to
other membrane proteins.
Membrane proteins
participate in many important biological
processes:
Ion pumps and channels regulate the ionic balance of
the cell and participate in biological energy
conversions, signal transmission in the nervous
system and in muscle activity.
Carriers of substances into and out of the
cell.
Cell surface receptors for hormones and signal
substances. Confer cell identity and participate in
immunological reactions.
Convert light to nerve signals in the eye.
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