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What happens
next?
The discovery of catalytic
RNA, also called ribozyme, has been of
great importance to both research and industry.
An important catalyst:
In addition to cutting and rejoining RNA, catalytic
RNA probably plays a major role in many biological
processes. Life processes often require intimate
cooperation between proteins and RNA. In the future
researchers will probably find that RNA rather than
protein-enzymes plays the leading role in many of
these processes.
Three-dimensional
structure: There are clear indications that
catalytic RNA possesses a specific three-dimensional
structure in the same manner as enzyme proteins. As
soon as scientists have described this structure, it
will be easier to understand the chemical reaction
mechanism for catalytic RNA.
Custom-designed
ribozyme: Catalytic RNA is a new and powerful
tool for gene technology. In the mail-house
catalogues used by researchers one can find "canned
ribozyme" - custom-designed enzymes which cut or join
RNA molecules with high precision.
Medical drugs: Within
biotechnology and medicine there are obvious
applications for catalytic RNA. For example,
genetically engineered plants can become virus
resistant by producing a ribozyme which can cut and
destroy the genetic material of the virus. One can
also custom-design ribozymes which can search out
infectious viruses and render them harmless. It might
even become possible at some future date to cure
hereditary diseases with the help of ribozymes.
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