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The Nobel Prize in Physiology or Medicine 1992

Activation of the immune system

Activation of the immune system in response to a specific antigen illustrates how a series of protein phosphorylation and dephosporylation reactions convert a cell surface event to changes in DNA transcription and cell replication.

A protein phosphatase in the lymphocyte is activated (when contacting the antigen-presenting cell)

Lymphocytes divide and the immune system is activated

The 1992 Prize in: