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The Nobel Prize in Physiology or Medicine 1993

Exon shuffling
During evolution, DNA segments coding for modules or domains in proteins have been duplicated and rearranged. By shuffling modules between genes, protein families have evolved.

Blood coagulation factors represent such a family. Its members contain similar domains in various combinations and numbers. P=protease domain, GF=growth factor domain, K="kringle"-domain.

 

Contents:
Introduction » DNA makes RNA makes protein » Genes in pieces » The discovery of split genes » Altesplicing » Exon shuffling » Splicing and diseases
These pages are based on material from the 1993 Physiology or Medicine Nobel Poster.
Credits and references for the poster »

The 1993 Prize in:

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