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ISBN 3-7643-2940-8 (Basel) |
| Table of Contents | |
| Preface | IX |
| Perspectives | |
| Alcohol in
human history B.L. Vallee |
1 |
| Section 1: Neuropharmacological aspects | |
| Reward and its
control by dynorphin peptides L. Terenius |
9 |
| Adaptation of
signal transduction in brain C. Alling, L. Gustavsson, C. Larsson, C. Lundqvist, D. Rodriguez and P. Simonsson |
19 |
| Protein kinase
C and adaptation to ethanol R. Roivainen, B. Hundle and R. O. Messing |
29 |
| Molecular
control of neuronal survival in the chick embryo S. Biffo, G. Dechant, H. Okazawa and Y.-A. Barde |
39 |
| Effects of
alcohol on gene expression in neural cells N. Wilke, M. Sganga, S. Barhite and M. F. Miles |
49 |
| The role of
the NMDA receptor in ethanol withdrawal P. L. Hoffman and B. Tabakoff |
61 |
| Molecular
diversity of glutamate receptors and their physiological
functions S. Nakanishi, M. Masu, Y: Bessho, Y. Nakajima, Y. Hayashi and R. Shigemoto |
71 |
| Multiple
dopamine receptors: The D3 receptor and actions of
substances of abuse J.-C. Schwartz, J. Diaz, N. Griffon, D. Levesque, M.-P. Martres and P. Sokoloff |
81 |
| Molecular
pharmacology of serotonin receptors P. R. Hartig |
93 |
| Alcohol, the
reward system and dependence G. F. Koob, S. Rassnick, S. Heinrichs and F. Weiss |
103 |
| Section 2: Biological markers and special clinical features | |
| Clinical
aspects on molecular probes, markers and metabolism U. Rydberg |
115 |
| Familial
alcoholism: Family, twin adoption and high risk studies J. Knop |
121 |
| Association
strategies in substance abuse G. R. Uhl |
133 |
|
PET-determination of benzodiazepine receptor binding in
studies on alcoholism L. Farde, S. Pauli, J.-E. Litton, C. Halldin, J. Neiman and G. Sedvall |
143 |
| Serotonin,
violent behavior and alcohol M. Linnoila, M. Virkkunen, T. George, M. Eckardt, J.D. Higley, D. Nielsen and D. Goldman |
155 |
| Neuropeptides
and alcohol addiction in monkeys J. M. van Ree, M. Kornet and C. Goosen |
165 |
| The role of
adenosine in mediating cellular and molecular responses to
ethanol I. Diamond and A. S. Gordon |
175 |
|
Helicobacter pylori alcohol dehydrogenase M. Salaspuro |
185 |
| Genetic
polymorphism of cytochrome P450. Functional consequences and
possible relationship to disease and alcohol toxicity M. Ingelman-Sundberg, I. Johansson, I. Persson, M. Oscarson, Y. Hu, L. Bertilsson, M.-L. Dahl and F. Sjöqvist |
197 |
|
Serotonin-altering medications and desire, consumption and
effects of alcohol treatment implications C.A. Naranjo and K.E. Bremner |
209 |
| Section 3: Enzymatic aspects | |
| The alcohol
dehydrogenase system H. Jörnvall |
221 |
| Drug
metabolism and signal transduction: Possible role of Ah
receptor and arachidonic acid cascade in protection from
ethanol toxicity D.W. Nebert |
231 |
| Recruitment of
enzymes and stress proteins as lens crystallins J. Piatigorsky, M. Kantorow, R. Gopal-Srivastava and S. l. Tomarev |
241 |
| X-ray
structure of PQQ-dependent methanol dehydrogenase M. Ghosh, A. Avezoux, C. Anthony, K. Harlos and C. C. F. Blake |
251 |
| NMR, alcohols,
protein solvation and protein denaturation K Wüthrich |
261 |
|
Crystallographic investigations of alcohol
dehydrogenases H. Eklund, S. Ramaswamy, B. V. Plapp, M. El-Ahmad, O. Danielsson, J.-O. Höög and H. Jörnvall |
269 |
| Retinoids and
the alcohol dehydrogenase gene family G. Duester |
279 |
| Alcohol and
acetaldehyde dehydrogenase gene polymorphism and
alcoholism D.I.N. Sherman, R.J. Ward, A. Yoshida and T. J. Peters |
291 |
| Site-directed
mutagenesis and enzyme properties of mammalian alcohol
dehydrogenases correlated with their tissue
distribution J.-O. Höög, M. Estonius and O. Danielsson |
301 |
| Control of
alcohol metabolism B. V. Plapp |
311 |
| Angiotensin
converting enzyme inhibitors and alcohol abuse J. E. Riordan |
323 |
| Section 4: Clinical aspects and pharmacological approaches | |
| Treatment of
alcoholism B. Jansson |
333 |
| Alcohol
sensitivity and dependence M. A. Schuckit |
341 |
| Treatment of
alcoholism as a chronic disorder C. P. O'Brien |
349 |
| Addiction and
the potential for therapeutic drug development P. A. J. Janssen |
361 |
| Therapeutic
lessons from traditional Oriental medicine to contemporary
Occidental pharmacology W.-M. Keung and B. L. Vallee |
371 |
| Potential gene
therapy for alcoholism R. O. Brady |
383 |
| Outlook:
Prospects for alcoholism treatment E. Gordis |
395 |
| Subject index | 405 |
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