Rolf M. Zinkernagel
Facts
Photo from the Nobel Foundation archive.
Rolf M. Zinkernagel
The Nobel Prize in Physiology or Medicine 1996
Born: 6 January 1944, Basel, Switzerland
Affiliation at the time of the award: University of Zurich, Institute of Experimental Immunology, Zurich, Switzerland
Prize motivation: “for their discoveries concerning the specificity of the cell mediated immune defence”
Prize share: 1/2
Work
When the body's cells are attacked by viruses, the immune system begins killing the infected cells. By studying mice, Rolf Zinkernagel and Peter Doherty proved in 1973 how the immune system recognises virus-ridden cells. A kind of white blood cell, the T-cell, kills the virus-ridden cells, but only if it recognises both the foreign substances, viruses, and certain substances from the body's own cells. The discovery has provided an important basis for producing vaccines and medicines against infectious diseases, and also for treating and understanding inflammatory diseases and cancer.
Nobel Prizes and laureates
Six prizes were awarded for achievements that have conferred the greatest benefit to humankind. The 12 laureates' work and discoveries range from proteins' structures and machine learning to fighting for a world free of nuclear weapons.
See them all presented here.
