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  The Nobel Prize in Chemistry 2004             Prevents self-polination Did you know that roses are bisexual? Most plants are like this – they’re hermaphrodites. With such an arrangement, one wonders what prevents plants from fertilising themselves. In fact, ubiquitin-mediated protein breakdown is involved: the plant recognises and rejects its…

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  The Nobel Prize in Chemistry 2004             Ubiquitin This is what the actual label looks like. It consists of a short polypeptide chain, a small protein that is so common in the cells of different organisms that it was early named ubiquitin, from the Latin ubique, ‘everywhere’. This protein…

  The Nobel Prize in Chemistry 2004           The most common reason for miscarriage is an error when the mother’s and the father’s chromosomes are to be separated in the formation of sex cells. Ubiquitin-marking plays an important role here. The picture shows a calf embryo.   How are sex cells…

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  The Nobel Prize in Chemistry 2004             What proteins are marked? Surprisingly many of the proteins created in the cell are faulty from the start. They must be broken down and rebuilt since they can damage the organism. But perhaps the most important reason for a cell to get…

Credits Production TWI: Narrator: Josette Simon Titles and Graphics: Kevin Cooney Editor: Gidon Benari Sound: Stuart Browne Researcher: Alex Gervin Production Manager: Kate Best Executive Producer: Rick Thomas Producer: Linda Daniel Camera: Sveriges Television AB – SVT Copyright Acknowledgements: Cell Press, an imprint of Elsevier Technion, Israel Institute of Technology Typoform for the Royal Swedish…

  The Nobel Prize in Chemistry 2004 The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2004 “for the discovery of ubiquitin-mediated protein degradation” jointly to Aaron Ciechanover, Avram Hershko and Irwin Rose       It has long been clear how proteins are built up in the…