Useful Links / Further Reading
| The Laureates |
| Aaron Ciechanover, Technion (Israel Institute of Technology) |
| Avram Hershko, Technion (Israel Institute of Technology) |
| Original Papers |
| Ciechanover, A., Hod, Y., and Hershko, A. (1978) “A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes”. Biochem. Biophys. Res. Commun. 81, pp. 1100-1105. |
| Hershko, A., Ciechanover, A., and Rose, I.A. (1979) “Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP”. Proc. Natl. Acad. Sci. USA 76, pp. 3107-3110. |
| Ciechanover, A., Heller, H., Elias, S., Haas, A.L., and Hershko, A. (1980) “ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation”. Proc. Natl. Acad. Sci. USA 77, pp. 1365-1368. |
| Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) “Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis”. Proc. Natl. Acad. Sci. USA 77, pp. 1783-1786. |
| Ciechanover, A., Heller, H., Katz-Etzion, R., and Hershko, A. (1981) “Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system”. Proc. Natl. Acad. Sci. USA 78, pp. 761-765. |
| Hershko, A., Heller, H., Elias, S., and Ciechanover, A. (1983) “Components of ubiquitin-protein ligase system”. J. Biol. Chem. 258, pp. 8206-8214. |
| Other Articles |
| Ciechanover, A. (1998) “The ubiquitin-proteasome pathway: on protein death and cell life”. EMBO J., 17, pp. 7151-7160. |
| Goldberg, A.L., Elledge, S.J. and Harper, J.W. (2001) “The cellular chamber of doom”. Scientific American, Jan 284 (1), pp. 56-61. |
| Hershko, A. and Ciechanover, A. (1998) “The ubiquitin system”. Annu. Rev. Biochem 67, pp. 425-479. |
| Weissman, A.M. (2001) “Themes and variations on ubiquitylation”. Nature reviews Molecular cell biology 2, pp. 169-178. |
Nobel Prizes and laureates
Six prizes were awarded for achievements that have conferred the greatest benefit to humankind. The 12 laureates' work and discoveries range from proteins' structures and machine learning to fighting for a world free of nuclear weapons.
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