From Dr Jekyll to Mr Hyde

 PrPc  

The prion protein exists in two forms. The normal, innocuous protein (PrPc) can change its shape to a harmful, disease-causing form (PrPSc). The conversion from PrPc to PrPSc then proceeds via a chain-reaction. When enough PrPSc proteins have been made they form long filamentous aggregates that gradually damage neuronal tissue. The harmful PrPSc form is very resistant to high temperatures, UV-irradiation and strong degradative enzymes.
PrPSc  

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MLA style: From Dr Jekyll to Mr Hyde. NobelPrize.org. Nobel Prize Outreach AB 2024. Sun. 17 Nov 2024. <https://www.nobelprize.org/prizes/medicine/1997/7823-from-dr-jekyll-to-mr-hyde/>

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