What is catalytic asymmetric synthesis?

Web Adapted Version of the Nobel Poster from the Royal Swedish Academy of Sciences

  The Nobel Prize in Chemistry 2001     
       
     
 

(R)-alanine
R refers to the Latin word rectus, meaning right.
(S)-alanine
S refers to the Latin word sinister, meaning left.

When alanine is produced in a laboratory under normal conditions, a mixture is obtained, half of which consists of (R)-alanine and half of (S)-alanine.

In an asymmetric synthesis an excess of one of these forms is produced. To achieve this, in a catalytic way – that is, with the aid of a molecule that speeds up the reaction without being consumed itself – is what this year’s Nobel Laureate’s have accomplished.

Since the cells’ actors are chiral, many pharmaceutical drugs also have to be chiral. Thus a flourishing pharmaceutical industry has grown up in the wake of the Laureates’ achievements.

 
 
     
 
Based on materials from the 2001 Nobel Poster for Chemistry.
 

To cite this section
MLA style: What is catalytic asymmetric synthesis?. NobelPrize.org. Nobel Prize Outreach AB 2024. Thu. 21 Nov 2024. <https://www.nobelprize.org/prizes/chemistry/2001/9100-what-is-catalytic-asymmetric-synthesis/>

Back to top Back To Top Takes users back to the top of the page

Nobel Prizes and laureates

Six prizes were awarded for achievements that have conferred the greatest benefit to humankind. The 12 laureates' work and discoveries range from proteins' structures and machine learning to fighting for a world free of nuclear weapons.

See them all presented here.

Illustration

Explore prizes and laureates

Look for popular awards and laureates in different fields, and discover the history of the Nobel Prize.